Showing posts with label confidence intervals. Show all posts
Showing posts with label confidence intervals. Show all posts

Sunday, July 21, 2019

Confidence Intervals -- If Only It Were That Simple

Confidence Interval: Statistics such as means (or averages) and medians are often calculated from data from a portion—or sample—of a population rather than from data for an entire population. Statistics based on sample data are called “sample statistics,” whereas those based on an entire population are called “population parameters.” A confidence interval is the range of values of a sample statistic that is likely to contain a population parameter, and that likeliness is expressed with a specific probability. For example, if a study of a sample of 1,500 Americans finds their average weight to be 150 pounds with a 95 percent confidence interval of plus/minus 25 pounds, this means that there is a 95 percent probability that the average weight of the entire American population is between 125 and 175 pounds. --Wm. Nöel & Judy Wang, Is Cannabis a Gateway Drug? Key Findings and Literature Review: A Report Prepared by the Federal Research Division, Library of Congress, Under an Interagency Agreement with the Office of the Director, National Institute of Justice, Office of Justice Programs, U.S. Department of Justice, Nov. 2018, at 3.

{T]here is a 5 percent chance the true value [of a 95% one-sided confidence interval] exceeds the bound. --President’s Council of Advisors on Science and Technology, Forensic Science in Criminal Courts: Ensuring Scientific Validity of Feature-Comparison Methods, Sept. 2016, at 153.
[T]he confidence level does not give the probability that the unknown parameter lies within the confidence interval. ... According to the frequentist theory of statistics, probability statements cannot be made about population characteristics: Probability statements apply to the behavior of samples. That is why the different term ‘confidence’ is used. --David H. Kaye & David A. Freedman, Reference Guide on Statistics, in Reference Manual on Scientific Evidence 211, 247 (Federal Judicial Center & National Research Council Committee on the Development of the Third Edition of the Reference Manual on Scientific Evidence eds., 3d ed. 2011).

Warning! ... [T]he fact that a confidence interval is not a probability statement about [an unknown value] is confusing. --Larry Wasserman, All of Statistics: A Concise Course in Statistical Inference 92-93 (2004) (emphasis in original).

Sunday, June 23, 2019

The Miami Dade Bullet-matching Study Surfaces in United States v. Romero-Lobato

Last month, the US District Court for the District of Nevada rejected another challenge to firearms toolmark comparisons. The opinion in United States v. Romero-Lobato, 1/ written by Judge Larry R. Hicks, relies in part on a six-year-old study that has yet to appear in any scientific journal. 2/ The National Institute of Justice (the research-and-development arm of the Department of Justice) funded the Miami-Dade Police Department Crime Laboratory "to evaluate the repeatability and uniqueness of striations imparted by consecutively manufactured EBIS barrels with the same EBIS pattern to spent bullets as well as to determine the error rate for the identification of same gun evidence." 3/ Judge Hicks describes the 2013 study as follows:
The Miami-Dade Study was conducted in direct response to the NAS Report and was designed as a blind study to test the potential error rate for matching fired bullets to specific guns. It examined ten consecutively manufactured barrels from the same manufacturer (Glock) and bullets fired from them to determine if firearm examiners (165 in total) could accurately match the bullets to the barrel. 150 blind test examination kits were sent to forensics laboratories across the United States. The Miami-Dade Study found a potential error rate of less than 1.2% and an error rate by the participants of approximately 0.007%. The Study concluded that “a trained firearm and tool mark examiner with two years of training, regardless of experience, will correctly identify same gun evidence.”
The "NAS Report" was the work of a large committee of scientists, forensic-science practitioners, lawyers, and others assembled by the National Academy of Sciences to recommend improvements in forensic science. A federal judge and a biostatistician co-chaired the committee. In 2009, four years after Congress funded the project, the report arrived. It emphasized the need to measure the error probabilities in pattern-matching tasks and discussed what statisticians call two-by-two contingency tables for estimating the sensitivity (true-positive probability) and specificity (true-negative probability) of the classifications. However, the Miami-Dade study was not designed to measure these quantities. To understand what it did measure, let's look at some of the details in the report to NIJ as well as what the court gleaned from the report (directly or indirectly).

A Blind Study?

The study was not blind in the sense of the subjects not realizing that they were being tested. They surely knew that they were not performing normal casework when they received the unusual samples and the special questionnaire with the heading "Answer Sheet: Consecutively Rifled EBIS-2 Test Set" asking such questions as "Is your Laboratory ASCLD/Lab Accredited?" That is not a fatal flaw, but it has some bearing -- not recognized in the report's sections on "external validity" -- on generalizing from the experimental findings to case work.  4/

Volunteer Subjects?

The "150 blind examination kits" somehow went to 201 examiners, not just in the United States, but also in "4 international countries." 5/ The researchers did not consider or reveal the performance of 36 "participants [who] did not meet the two year training requirement for this study." (P. 26). How well they did in comparison to their more experienced colleagues would have been worth knowng, although it would have been hard to draw a clear concolusions since there so few errors on the test. In any event, ignoring the responses from the trainees "resulted in a data-producing sample of 165 participants." (P. 26).

These research subjects came from emails sent to "the membership list for the Association of Firearm and Tool Mark Examiners (AFTE)." (Pp. 15-16). AFTE members all "derive[] a substantial portion of [their] livelihood from the examination, identification, and evaluation of firearms and related materials and/or tool marks." (P. 15). Only 35 of the 165 volunteers were certified by AFTE (p. 30), and 20 worked at unaccredited laboratories (P. 31).

What Error Rates?

Nine of the 165 fully trained subjects (5%) made errors (treating "inconclusive" as a correct response). The usual error rates (false positives and false negatives) are not reported because of the design of the "blind examination kits." The obvious way to obtain those error rates is to ask each subject to evaluate pairs of items -- some from the same source and some from different sources (with the examiners blinded to the true source information known to the researchers). Despite the desire to respond to the NAS report, the Miami Dade Police Department Laboratory did not make "kits" consisting of such a mixture of pairs of same-source and different-source bullets.

Instead, the researchers gave each subject a single collection of ten bullets produced by firing one manufacturer's ammunition in eight of the ten barrels. (Two of these "questioned bullets," as I will call them, came from barrel 3 and two from barrel 9; none came from barrel 4.) Along with the ten questioned bullets, they gave the subjects eight pairs of what we can call "exemplar bullets." Each pair of exemplar bullets came from two test fires of the same eight of the ten consecutively manufactured barrels (barrels 1-3 and 5-9). The task was to associate each questioned bullet with an exemplar pair or to decide that it could not be associated with any of the eight pairs. Or, the research subjects could circle "inconclusive" on the questionnaire. Notice that almost all the questioned bullets came from the barrels that produced the exemplar bullets -- only two such barrels were not a source of an unknown -- and bullets from only one barrel that produced a questioned bullet was not in the exemplar set.

This complicated and unbalanced design raises several questions. After associating an unknown bullet with an exemplar pair, will an examiner seriously consider the other exemplar pairs? After eliminating a questioned bullet as originating from, say seven exemplar-pair barrels, would he be inclined to pick one of the remaining three? Because of the extreme overlap in the sets, on average, such strategies would pay off. Such interactions could make false eliminations less probable, and true associations more probable, than with the simpler design of a series of single questioned-to-source comparisons.

The report to NIJ does not indicate that the subjects received any instructions to prevent them from having an expectation that most of the questioned bullets would match some pair of exemplar bullets. The only instructions it mentions are on a questionnaire that reads:
Please microscopically compare the known test shots from each of the 8 barrels with the 10 questioned bullets submitted. Indicate your conclusion(s) by circling the appropriate known test fired set number designator on the same line as the alpha unknown bullet. You also have the option of Inconclusive and Elimination. ...
Yet, the report confidently asserts that "[t]he researchers utilized an 'open set' design where the participants had no expectation that all unknown tool marks should match one or more of the unknowns." (P. 28).

To be sure, the study has some value in demonstrating that the subset of the subjects could perform a presumably difficult task in associating unknown bullets with exemplar ones. Moreover, whatever one thinks of this alleged proof of "uniqueness," the results imply that there are microscopic (or other) features of marks on bullets that vary with the barrel through which they traveled. But the study does not supply a good measure of examiner skill at making associations in fully "open" situations.

A 0.007% Error Rate?

As noted above, but not in the court's opinion, 5% of the examiners made some kind of error. That said, there were only 12 false-positive associations or false-negative ones (outright eliminations) out of 165 x 10 = 1,650 answers. (I am assuming that every subject completed the questionnaire for every unknown bullet.) That is an overall error proportion of 12/1650 = 0.007 = 0.7%.

The researchers computed the error rate slightly differently. They only reported the average error rate for the 165 experienced examiners. The vast majority (156) made no errors. Six made 1 error, and 3 made 2. So the average examiner's proportion of errors was [156(0) + 6(0.1) + 3(0.2)]/165 = 0.007. No difference at all.

This 0.007 figure is 100 times the number the court gave. Perhaps the opinion had a typographical error -- an adscititious  percentage sign that the court missed when it reissued its opinion (to correct other typographical errors). The error rate is still small and would not affect the court's reasoning.

But the overall proportion of errors and the average-examiner error rate could diverge. The report gives the error proportions for the 9 examiners who made errors as 0.1 (6 of the examiners) and 0.2 (another 3 examiners). Apparently, all of the 9 erroneous examiners evaluated all 10 unknowns. What about the other 156 examiners? Did all of them evaluate all 10? The worst-case scenario is that every one of the 156 error-free examiners answered only one question. That supplies only 156 correct answers. Add this number to the 12 incorrect answers, and we have an error proportion of 12/168 = 0.7 = 7% -- another 100 times larger than the court's number.

However, this worst-case scenario did not occur. The funding report states that "[t]here were 1,496 correct answers, 12 incorrect answers and 142 inconclusive answers." (P. 15). The sum of these numbers of answers is 1,650. Did every examiner answer every question? Apparently so. For this 100% completion rate, the report's emphasis on the examiner average (which is never larger and often smaller than the overall error proportion) is a distinction without a difference.

There is a further issue with the number itself. "Inconclusives" are not correct associations. If every examiner came back with "inconclusive" for every questioned bullet, the researchers hardly could report the zero error rate as validating bullet-matching. 7/ From the trial court's viewpoint, inconclusives just do not count. They do not produce testimony of false associations or of false eliminations. The sensible thing to do, in ascertaining error rates for Daubert purposes, is to toss out all "inconclusives."

Doing so here makes little difference. There were 142 inconclusive answers. (P. 15). If these were merely "not used to calculate the overall average error rates," as the report claims (p. 32), the overall error proportion was 12/(1605 - 142) = 12/1508 = 0.008 -- still very small (but still difficult to interpret in terms of the parameters of accuracy for two-by-two tables).

The report to NIJ discussed another finding that, at first blush, could be relevant to the evidence in this case: "Three of these 35 AFTE certified participants reported a total of four errors, resulting in an error rate of 0.011 for AFTE Certified participants." (P. 30). Counter-intuitively, this 1% average is larger than the reported average error rate of 0.007 for all the examiners.

That the certified examiners did worse than the uncertified ones may be a fluke. The standard error in the estimate of the average-examiner error rate was 0.32 (p. 29), which indicates that, despite the observed difference in the sample data, the study does not reveal whether certified examiners generally do better or worse than uncertified ones. 7/

A Potential Error Rate?

Finally, the court's reference to "a potential error rate of less than 1.2%" deserves mention. The "potential error rate" is tricky. Potentially, the error rate of individual practitioners like the ones who volunteered for the study, with no verification step by another examiner, could be larger (or smaller). There is no sharp and certain line that can be drawn for the maximum possible error rate. (Except that it could not be 100%.)

In this case, 1.2% is the upper limit of a two-sided confidence interval. The Miami Dade authors wrote that:
A 95% confidence interval for the average error rate, based on the large sample distribution of the sample average error rate, is between 0.002 and 0.012. Using a confidence interval of 95%, the error rate is no more than 0.012, or 1.2%.
A 95% confidence interval means that if there had been a large number of volunteer studies just like this one, making random draws from an unchanging population of volunteer-examiners and having these examiners perform the same task in the same way, about 95% of the many resulting confidence intervals would encompass the true value for the entire population. But the hypothetical confidence intervals would vary from one experiment to the next. We have a statistical process -- a sort of butterfly net -- that is broad enough to capture the unknown butterfly in about 95% of our swipes. The weird thing is that with each swipe, the size and center of the net change. On the Miami Dade swipe, one end of the net stretched out to the average error rate of 1.2%.

So the court was literally correct. There is "a potential error rate" of 1.2%. There is also a higher potential error rate that could be formulated -- just ask for 99% "confidence." Or lower -- try 90% confidence. And for every confidence interval that could be constructed by varying the confidence coefficient, there is the potential for the average error rate to exceed the upper limit. Such is the nature of a random variable. Randomness does not make the upper end of the estimate implausible. It just means that it is not "the potential error rate," but rather a clue to how large the actual rate of error for repeated experiments could be.

Contrary to the suggestion in Romero-Lobato, that statistic is not the "potential rate of error" mentioned in the Supreme Court's opinion in Daubert v. Merrell Dow Pharmaceuticals, Inc., 509 U.S. 579 (1993). The opinion advises judges to "ordinarily ... consider the known or potential rate of error, see, e.g., United States v. Smith, 869 F. 2d 348, 353-354 (CA7 1989) (surveying studies of the error rate of spectrographic voice identification technique)." The idea is that along with the validity of an underlying theory, how well "a particular scientific technique" works in practice affects the admissibility of evidence generated with that technique. When the technique consists of comparing things like voice spectrograms, the accuracy with which the process yields correct results in experiments like the ones noted in Smith are known error rates. That is, they are known for the sample of comparisons in the experiment. (The value for all possible examiners' comparisons is never known.)

These experimentally determined error rates are also a "potential rate of error" for the technique as practiced in case work. The sentence in Daubert that speaks to "rate of error" continues by adding, as part of the error-rate issue, "the existence and maintenance of standards controlling the technique's operation, see United States v. Williams, 583 F. 2d 1194, 1198 (CA2 1978) (noting professional organization's standard governing spectrographic analysis)." The experimental testing of the technique shows that it can work -- potentially; controlling standards ensure that it will be applied consistently and appropriately to achieve this known potential. Thus, Daubert's reference to "potential" rates does not translate into a command to regard the upper confidence limit (which merely accounts for sampling error in the experiment) as a potential error rate for practical use.

NOTES
  1. No. 3:18-cr-00049-LRH-CBC, 2019 WL 2150938 (D. Nev. May 16, 2019).
  2. That is my impression anyway. The court cites the study as Thomas G. Fadul, Jr., et al., An Empirical Study to Improve the Scientific Foundation of Forensic Firearm and Tool Mark Identification Utilizing Consecutively Manufactured Glock EBIS Barrels with the Same EBIS Pattern (2013), available at https://www.ncjrs.gov/pdffiles1/nij/grants/244232.pdf. The references in Ronald Nichols, Firearm and Toolmark Identification: The Scientific Reliability of the Forensic Science Discipline 133 (2018) (London: Academic Press), also do not indicate a subsequent publication.
  3. P. 3. The first of the two "research hypotheses" was that "[t]rained firearm and tool mark examiners will be able to correctly identify unknown bullets to the firearms that fired them when examining bullets fired through consecutively manufactured barrels with the same EBIS pattern utilizing individual, unique and repeatable striations." (P. 13). The phrase "individual, unique and repeatable striations" begs a question or two.
  4. The researchers were comforted by the thought that "[t]he external validity strength of this research project was that all testing was conducted in a crime laboratory setting." (P. 25). As secondary sources of external validity, they noted that "[p]articipants utilized a comparison microscope," "[t]he participants were trained firearm and tool mark examiners," "[t]he training and experience of the participants strengthened the external validity," and "[t]he number of participants exceeded the minimum sample size needed to be statistically significant." Id. Of course, it is not the "sample size" that is statistically significant, but only a statistic that summarizes an aspect of the data (other than the number of observations).
  5. P. 26 ("A total of 201 examiners representing 125 crime laboratories in 41 states, the District of Columbia, and 4 international countries completed the Consecutively Rifled EBIS-2 Test Set questionnaire/answer sheet.").
  6. Indeed, some observers might argue that an "inconclusive" when there is ample information to reach a conclusion is just wrong. In this context, however, that argument is not persuasive. Certainly, "inconclusives" can be missed opportunities that should be of concern to criminalists, but they are not outright false positives or false negatives.
  7. The opinion does not state whether the examiner in the case -- "Steven Johnson, a supervising criminalist in the Forensic Science Division of the Washoe County Sheriff's Office" -- is certified or not, but it holds that he is "competent to testify" as an expert.

Saturday, March 30, 2019

Can P-values or Confidence Intervals Prove Non-association?

Last week, the scientific community heard two prominent calls to end to the labeling of results of statistical studies as statistically "significant" or "not significant." One of the manifestos (Amrhein et al.) is particularly irate about negative claims -- conclusions of "no association" based on sample data that are not extreme enough to reject the null hypothesis. The authors "are frankly sick of seeing such nonsensical 'proofs of the null' and claims of non-association in presentations, research articles, reviews and instructional materials." The "pervasive problem," as they articulate it, is in the box on the right. It is a recurring issue in toxic tort an other litigation.
PERVASIVE PROBLEM
Let’s be clear about what must stop: we should never conclude there is ‘no difference’ or ‘no association’ just because a P value is larger than a threshold such as 0.05 or, equivalently, because a confidence interval includes zero. Neither should we conclude that two studies conflict because one had a statistically significant result and the other did not. These errors waste research efforts and misinform policy decisions. 1/
It is hard to disagree with the first observation in the box. Logically, we cannot conclude that the null hypothesis is true "just because a P value is larger than a threshold." For one thing, if the study lacks power, random error plausibly could be the source of the observed difference. However, this is not a sufficient reason to abjure hypothesis tests. It is a reason to attend to power. If a study has ample power and is well designed, then it is not so obvious that it wastes research efforts or misinforms policy decisions to conclude that the failure to achieve statistical significance at a rather undemanding level demonstrates the lack of a true association.

The second observation also is literally correct. Different outcomes of a null hypothesis significance test are not logically sufficient to establish a conflict between the studies. In 2013, a paper in the International Journal of Cardiology reported "that the use of selective COX-2 inhibitors [such as Vioxx] was not associated with atrial fibrillation risk" because the researchers did not find a statistically significant association. 2/ But a 2011 study in the British Medical Journal had found just such an association. 3/ It might seem that the second study is in conflict with the first, but as Amrhein et al. explain:
The researchers describing their statistically non-significant results found a risk ratio of 1.2 (that is, a 20% greater risk in exposed patients relative to unexposed ones). They also found a 95% confidence interval that spanned everything from a trifling risk decrease of 3% to a considerable risk increase of 48% (P = 0.091; our calculation). The researchers from the earlier, statistically significant, study found the exact same risk ratio of 1.2. That study was simply more precise, with an interval spanning from 9% to 33% greater risk (P = 0.0003; our calculation).

It is ludicrous to conclude that the statistically non-significant results showed “no association”, when the interval estimate included serious risk increases; it is equally absurd to claim these results were in contrast with the earlier results showing an identical observed effect. Yet these common practices show how reliance on thresholds of statistical significance can mislead us ... . 4/
So the results of the second study do not undermine those of the first. The studies provide consistent point estimates. The second one merely has a smaller standard error. As such, it does not merit as much weight, but it is fully consistent with the first result. 5/

What happens, however, when the point estimates of the relative risk are different? Is "no association" a reasonable statement when the confidence interval is tightly centered around RR = 1? Suppose, for example, that the second study produced a 95% confidence interval of RR = 1.0 ± 0.2. From a maximum likelihood standpoint, "no association" is the best estimate. Would it still be ludicrous to describe the observed RR of 1 (no difference in the risk) as proof of "no association"?

Amrhein et al. do not answer this specific question, but they grudgingly accept the idea of proof of "no association" in the form of no practical importance. As stated at the outset, they are "frankly sick of seeing such nonsensical 'proofs of the null' ... ." They argue that all values inside a confidence interval are "compatible" with the data (as are some outside of the interval), implying that you cannot single out any one value to the exclusion of the others. But they also propose that some values are more compatible than others. Is compatibility a likelihood? A probability? Something else? In the end, their answer to the question of whether the data can be said to prove a negative -- that there is no true association -- is this: "if you deem all of the values inside the interval to be practically unimportant, you might then be able to say something like ‘our results are most compatible with no important effect’." 6/

NOTES
  1. Valentin Amrhein, Sander Greenland, Blake McShane et al., Comment, Retire Statistical Significance, 567 Nature 305, 305-06 (2019).
  2. T.-F. Chao, C.-J. Liu, S.-J. Chen, K.-L. Wang, Y.-J. Lin, S.-L. Chang, et al., The Association Between the Use of Non-steroidal Anti-inflammatory Drugs and Atrial Fibrillation: a Nationwide Case–control Study, 168 Int’l J. Cardiology 312 (2013).
  3. M. Schmidt, C.F. Christiansen, F. Mehnert, K.J. Rothman, & H.T. Sørensen, Non-steroidal Anti-inflammatory Drug Use and Risk of Atrial Fibrillation or Flutter: Population Based Case-control Study, 343 Brit. Med. J. d3450 (2011).
  4. Amrhein, supra note 1, at 306..
  5. In fact, it lends strength to the conclusion that the true relative risk exceeds 1. Morten Schmidt & Kenneth J. Rothman, Mistaken Inference Caused by Reliance on and Misinterpretation of a Significance Test, 177(3) Int'l J. Cardiology 1089, 1090 (2014) (meta-analysis give a CI of 1.1 to 1.3).
  6. Amrhein, supra note 1, at 307.

Friday, November 23, 2018

Muddling Through the Measurement of IQ

IQ scores are a critical component in the diagnosis of intellectual disability. That measurements of IQ are subject to various sources of measurement error is widely appreciated, but by and large, lawyers and psychologists have supplied rather imprecise -- and sometimes incorrect -- explanations of the statistics involved. A recent example is Intellectual Disability and the Death Penalty: Current Issues and Controversies, a book intended as "a valuable resource for mental health experts, attorneys, investigators, mitigation specialists, and other members of legal teams, as well as judges." 1/ The authors explain the "standard scores" that put the mean IQ score in the population at 100 as follows:
A person's standard score on a test is calculated by transforming the individual's obtained raw score on Test A (e.g., the sum of the number of correct responses on a test) using the population's known mean and standard deviation on Test A, which transforms the individual's test performance onto a common metric allowing us to compare his or her score to anyone else tested with Test A. Standard scores are possible only for tests where, if administered to the entire population, the distribution of all test scores on said test would be normally distributed ... . A percentile score is one form of a standard score that permits the interpretation of a person's performance in relation to a reference group. Although not a requirement, in the case of many psychological tests the scale for standard scores is set to have a mean or average score of 100 and a standard deviation of 15. Thus, a test performance that results in a standard score of 70 is said to be "significantly" below average or approximately two standard deviations below the population mean. A standard deviation is a unit of measure that indicates the distance from the average. During the standardization phase of the development of a standardized test, the test and its items are administered to a large anc representative sample of the reference group of interest or population. This is generally referred to as the standardization sample or norming group. From this norming group, the test developers compute the population's mean score and standard deviation on the test. The mean score and standard deviation are essential to transforming subsequently obtained raw scores (i.e., the sum of the number of correct items) on said test to a standard scale score (e.g., intelligence quotient, or IQ). 2/
Percentiles and Standard Scores

Standard scores have some value in "compar[ing one individual's] score to anyone else tested with Test A." Unlike raw scores, they incorporate the variance in the scores across different test-takers into the reported score. They are perhaps more useful for comparing scores from different tests (or different forms of the same test, or from tests administered to populations that are changing over time)

But whatever the motivation for a standardized reporting scale, it is strange to describe percentiles as standard scores. A standard score is just a particular linear transformation of a raw score that specifies "the number of standard deviations above (+) or below (-) the mean you are." 3/ As an example, suppose that the raw-score population mean for "Test A" is 60; that the population standard deviation is 12; and that a test taker has a raw score of 50. The standard score is 5/6s of a standard deviation below the mean: z = (50 - 60)/12 = -5/6 = -0.83.

To translate the raw score (or the corresponding z-score of -0.83) into a percentile, we need to know how the raw scores are distributed. For example, if raw scores were uniformly distributed from about 39 to 81, then some 26% of them would be 50 or less. If the raw scores were normally distributed (with the same mean and standard deviation), then 20% of the population would have a raw score of 50 (or less). Other distributions would produce other percentiles. Consequently, the percentile is not "one form of a standard score." At best, the percentile can be deduced from the standard score and other information.

A Standardized Scale Does Not Require Normality

Why are "[s]tandard scores ... possible only for tests where, if administered to the entire population, the distribution of all test scores on said test would be normally distributed"? Standard scores can be constructed for any distribution of test scores with a defined mean and standard deviation. Normality may be convenient or common, but it is not essential to a standardized score scale.

So What?

Not much turns on these corrections to the explanation in Intellectual Disability and the Death Penalty. IQ scores are more or less normally distributed, and the use of IQ scores of 70 and below (z ≤ -2) as the range in which an individual can be diagnosed as intellectually disabled limits the diagnosis to no more than roughly 2.3% of the general population.

But why should "a standard score of 70 [be] said to be 'significantly' below average"? Why is not an IQ score of 71 -- or even 80 -- significantly below the mean of 100? There is no statistical reason to focus on 70 as a cut off. In Hall v. Florida, 572 U.S. 5 (2014), a  majority of the Supreme Court was content with categorically excluding from the zone of intellectual disability (for the purpose of deciding potential eligibility for capital punishment) all defendants with true IQ scores above 70. Yet, no one could explain the basis for this fundamental choice. It is a convention currently in vogue among experts who want to have some such threshold. 4/

Quantifying Measurement Error

At the same time that the Court limited eligibility for the constitutional exemption from capital punishment because of intellectual disability to a small fraction of the population by approving of the z ≤ -2 range for true scores, it held that a slightly higher cutoff for observed scores was constitutionally necessary to ensure that random error in measuring IQ does not preclude too many defendants with true scores of 70 or less from consideration. Intellectual Disability and the Death Penalty explained this refinement as follows:
The Supreme Court of the United States in Hall v. Florida ruled that states must consider the test's standard error of measurement when interpreting obtained IQ scores in cases where the defendant is making an intellectual decision claim. ...
The standard error of measurement (SEM) is a direct measure of the test's reliability and is computed by administering the test to a large and representative sample of the population to be assessed on the test and computing the test's reliability coefficient, which can then be translated into an average error of measurement for the population ... . Generally, the SEM is computed and then used to create confidence intervals around the obtained standard scores (e.g., 95% certainty). A confidence interval of 95% represents a statistical certainty that, based on the knowledge of this test's reliahility coefficient, there is a 95% chance that the person's true score falls within a confidence interval that is +/-2 times the test's SEM. Thus, a professional reporting on an assessed individual's "obtained" full-scale IQ score of 70 on IQ Test A and knowing that Test A has a SEM of 2.5 around its full-scale IQ score, he would report that there is a 95% certainty that the assessed person's "true" full-scale IQ score falls within the range of 65-75 (i.e., 2x2.5= +/-5 points). 5/
This passage is garbled in two ways. To begin with, SEM is not "a direct measure of the test's reliability." It is a statistic derived from "the test's reliability coefficient." There are many ways to estimate reliability, and the logic behind the move from reliability to SEM is subtle. A better statistic for estimating the uncertainty in the observed score would be the standard error of estimate (SEE). The SEM is an average across all scores. The SEE takes into account the fact that uncertainty increases as one moves away from the population mean (IQ = 100). A description of the SEE can be found elsewhere. 6/

Second, the 95% in a 95% confidence interval is neither a "statistical certainty" nor "a 95% chance that the person's true score falls within [the computed] confidence interval." This interpretation of "confidence" is ubiquitous -- and widely known (to statisticians) to be wrong. The misinterpretation was apparent in the dissenting opinion written for four Justices by Justice Alito. It probably was implicit in the majority opinion penned by Justice Kennedy. Although we would expect (in the long run) 95% of all 95% confidence intervals  to contain the true value, the probability that a particular interval covers the true score cannot be computed with the machinery of confidence intervals. 7/ Interval estimates that can be said to provide such probabilities require Bayes theorem. Again, discussion and examples for IQ scores are available elsewhere. 8/

Clinical psychologists, lawyers, and judges are not statisticians. They do not have to compute means, standard deviations, standard errors, confidence intervals, or Bayesian credible regions. Nevertheless, to become more astute users of such statistics, they need a better understanding of the reasoning behind standard scores and expressions for measurement error.

NOTES
  1. Marc L. Tassé & John H. Blume, Intellectual Disability and the Death Penalty: Current Issues and Controversies vii (Prager 2018).
  2. Id. at 87.
  3. Penn State University Eberly College of Science, STAT 100: Statistical Concepts and Reasoning § 5.2 (2018), https://onlinecourses.science.psu.edu/stat100/node/13/
  4. David H. Kaye, Deadly Statistics: Quantifying an "Unacceptable Risk" in Capital Punishment, 16 Law, Probability & Risk 7-34 (2017), http://ssrn.com/abstract=2788377.
  5. Tassé & Blume, supra note 1, at 90.
  6. Kaye, supra note 4.
  7. For an elaboration in legal settings, see David H. Kaye, Apples and Oranges: Confidence Coefficients and the Burden of Persuasion, 73 Cornell L. Rev. 54 (1987).
  8. Kaye, supra note 4.
POSTINGS ON IQ SCORES AND CAPITAL PUNISHMENT

Wednesday, October 11, 2017

District Court Rejects Defendant's Reliance on PCAST Report as a Reason to Exclude Fingerprint Evidence

Yesterday, the U.S. District Court for the Northern District of Illinois rejected a defendant's motion to exclude a latent fingerprint identification on the theory that "the method used is not sufficiently reliable foundationally or as applied to his case." 1/ The court also precluded, as too "distracting," cross-examination of the FBI latent-print examiner about the FBI's infamous error in apprehending of Brandon Mayfield as the Madrid train bomber.

I. "Foundational Validity"

The "foundational validity" challenge came out of the pages of the 2016 PCAST Report. 2/ The PCAST Report seems to equate what it calls "foundational validity" for subjective pattern-matching methods to multiple "black box studies" demonstrating false-positive error probabilities of 5% or less, and it argues that Federal Rule of Evidence 702 requires such a showing of validity.

That this challenge would fail is unsurprising. According to the Court of Appeals for the Seventh Circuit, latent print analysis need not be scientifically valid to be admissible. Furthermore, even if the Seventh Circuit were to reconsider this questionable approach to the admissibility of applications of what the FBI and DHS call "the science of fingerprinting," the PCAST Report concludes that latent print comparisons have foundational scientific validity as defined above.

A. The Seventh Circuit Opinion in Herrera

Scientific validity is not a foundational requirement in the legal framework applied to latent print identification by the Court of Appeals for the Seventh Circuit. In United States v. Herrera, 3/ Judge Richard Posner 4/ observed that "the courts have frequently rebuffed" any "frontal assault on the use of fingerprint evidence in litigation." 5/ Analogizing expert comparisons of fingerprints to "an opinion offered by an art expert asked whether an unsigned painting was painted by the known painter of another painting" and even to eyewitness identifications, 6/ the court held these comparisons admissible because "expert evidence is not limited to 'scientific' evidence," 7/ the examiner was "certified as a latent print examiner by the International Association for Identification," 8/ and "errors in fingerprint matching by expert examiners appear to be very rare." 9/ To reach the last -- and most important -- conclusion, the court relied on the lack of cases of fingerprinting errors within a set of DNA-based exonerations (without indicating how often fingerprints were introduced in those cases), and its understanding that the "probability of two people in the world having identical fingerprints ... appears to be extremely low." 10/

B. False-positive Error Rates in Bonds

In the new district court case of United States v. Bonds, Judge Sara Ellis emphasized the court of appeals' willingness to afford district courts "wide latitude in performing [the] gate-keeping function." Following Herrara (as she had to), she declined to require "scientific validity" for fingerprint comparisons. 11/ This framework deflects or rejects most of the PCAST report's legal reasoning about the need for scientific validation of all pattern-matching methods in criminalistics. But even if "foundational validity" were required, the PCAST Report -- while far much more skeptical of latent print work than was the Herrera panel -- is not so skeptical as to maintain that latent print identification is scientifically invalid. Judge Ellis quoted the PCAST Report's conclusion that "latent fingerprint analysis is a foundationally valid subjective methodology—albeit with a false positive rate that is substantial and is likely to be higher than expected by many jurors based on longstanding claims about the infallibility of fingerprint analysis."

Bonds held that the "higher than expected" error rates were not so high as to change the Herrera outcome for nonscientific evidence. Ignoring other research into the validity of latent-print examinations, Judge Ellis wrote that "[a]n FBI study published in 2011 reported a false positive rate (the rate at which the method erroneously called a match between a known and latent print) of 1 in 306, while a 2014 Miami-Dade Police Department Forensic Services Bureau study had a false positive rate of 1 in 18."

Two problems with the sentence are noteworthy. First, it supplies an inaccurate definition of a false positive rate. "[T]he rate at which the method erroneously called a match between a known and latent print" would seem to be an overall error rate for positive associations (matches) in the sample of prints and examiners who were studied. For example, if the experiment used 50 different-source pairs of prints and 50 same-source pairs, and if the examiners declared 5 matches for the different-sources and 5 for the same-source pairs, the erroneous matches are 5 out of 100, for an error rate of 5%. However, the false-positive rate is the proportion of positive associations reported for different-source prints. When comparing the 50 different-source pairs, the examiners erred in 5 instances, for a false-positive rate of 5/50 = 10%. In the 50 same-source pairs, there were no opportunities for a false negative. Thus, the standard definition of a false-positive error rate gives the estimate of 0.1 for the false-positive probability. This definition makes sense because none of the same-source pairs in the sample can contribute to false-positive errors.

Second, the sentence misstates the false positive rates reported in the two studies. Instead of "1 in 306," the 2011 Noblis-FBI experiment found that "[s]ix false positives occurred among 4,083 VID [value for identification] comparisons of nonmated pairs ... ." 12/ In other words (or numbers), the reported false-positive rate (for an examiner without the verification-by-another-examiner step) was 6/4083 = 1/681. This is the only false-positive rate in the body of the study. An online supplement to the article includes "a 95% confidence interval of 0.06% to 0.3% [1 in 1668 to 1 in 333]." 13/ A table in the supplement also reveals that, excluding conclusions of "inconclusive" from the denominator, as is appropriate from the standpoint of judges or jurors, the rate is 6/3628, which corresponds to 1 in 605.

Likewise, the putative rate of 1/18 does not appear in the unpublished Miami-Dade study. A table in the report to a funding agency states that the "False Positive Rate" was 4.2% "Without Inconclusives."14/This percentage corresponds to 1 in 24.

So where did the court get its numbers? They apparently came from a gloss in the PCAST Report. That report gives an upper (but not a lower) bound on the false-positive rates that would be seen if the studies used an enormous number of random samples of comparisons (instead of just one). Bending over backwards to avoid incorrect decisions against defendants, PCAST stated that the Noblis-FBI experiment indicated that "the rate could be as high as 1 error in 306 cases" and that the numbers in the Miami-Dade study admit of an error rate that "could be as high as 1 error in 18 cases." 15/ Of course, the error rates in the hypothetical infinite population could be even higher. Or they could be lower.

III. Discussing Errors at Trial

The PCAST Report accepts the longstanding view that traces of the patterns in friction ridge skin can be used to associate latent prints that contain sufficient detail with known prints. But it opens the door to arguments about the possibility of false positives. Bonds wanted to confine the analyst to presenting the matching features or, alternatively, to declare a match but add that the "level of certainty of a purported match is limited by the most conservative reported false positive rate in an appropriately designed empirical study thus far (i.e., the 1 in 18 false positive rate from the 2014 Miami-Dade study)."

Using a probability of 1 in 18 to describe the "level of certainty" for the average positive association made by examiners like those studied to date seems "ridiculous." Cherry-picking a distorted number from a single study is hardly sound reasoning. And even if 1/18 were the best estimate of the false-positive probability that can be derived from the totality of the scientific research, applying it explain the "level of certainty" one should have that the examiner's conclusion would not be straightforward. For one thing, the population-wide false-positive probability is not the probability that a given positive finding is false! Three distinct probabilities come into play. 16/ Explaining the real meaning of an estimate of the false-positive probability from PCAST's preferred "black-box" studies in court will be challenging for lawyers and criminalists alike. Merely to state that a number like 1/18 goes to "the weight of the evidence" and can be explored "on cross examination," as Judge Ellis did, is to sweep this problem under the proverbial rug -- or to put it aside for another day.

NOTES
  1. United States v. Myshawn Bonds, No. 15 CR 573-2 (N.D. Ill. Oct. 10, 2017).
  2. Executive Office of the President, President’s Council of Advisors on Science and Technology, Report to the President: Forensic Science in Criminal Courts: Ensuring Scientific Validity of Feature-Comparison Methods, Sept. 2016).
  3. 704 F.3d 480 (7th Cir. 2013).
  4. For remarks on another opinion from the judge, see Judge Richard Posner on DNA Evidence: Missing the Trees for the Forest?, Forensic Sci., Stat. & L., July 19, 2014, http://for-sci-law.blogspot.com/2014/07/judge-richard-posner-on-dna-evidence.html. 
  5. Herrera, 704 F.3d at 484.
  6. Id. at 485-86.
  7. Id. at 486.
  8. Id.
  9. Id. at 487.
  10. Id.
  11. Judge Ellis stated that she "agree[d] with Herrera's broader reading of Rule 702's reliability requirement."
  12. Bradford T. Ulery, R. Austin Hicklin, JoAnn Buscaglia, & Maria Antonia Roberts, Accuracy and Reliability of Forensic Latent Fingerprint Decisions, 108(19) Proc. Nat’l Acad. Sci (USA) 7733-7738 (2011).
  13. Available at http://www.pnas.org/content/suppl/2011/04/19/1018707108.DCSupplemental/Appendix.pdf.
  14. Igor Pacheco, Brian Cerchiai, Stephanie Stoiloff, Miami-Dade Research Study for the Reliability of the ACE-V Process: Accuracy & Precision in Latent Fingerprint Examinations, Dec. 2014, at 53 tbl. 4.
  15. PCAST Report, supra note 2, at 94-95.
  16. The False-Positive Fallacy in the First Opinion to Discuss the PCAST Report, Forensic Sci., Stat. & L., November 3, 2016, http://for-sci-law.blogspot.com/2016/11/the-false-positive-fallacy-in-first.html.

Sunday, December 11, 2016

PCAST’s Sampling Errors (Part II: Getting More Technical)

The report to the President on Forensic Science in Criminal Courts: Ensuring Scientific Validity of Feature-Comparison Methods from the President’s Council of Advisors on Science and Technology emphasizes the need for research to assess the accuracy of the conclusions of criminalists who compare the features of identification evidence — things like fingerprints, toolmarks, hairs, DNA, and bitemarks. To this extent, it treads on firm (and well-worn) ground.

It also stresses the need to inform legal factfinders — the judges and jurors who try cases with the assistance of such evidence — of the false-positive error rates discovered in comprehensive and well designed studies with large sample sizes. This too is a laudable objective (although the specificity, which is the complement of the false-negative probability, also affects the probative value of the evidence and therefore should be incorporated into a presentation that indicates probative value).

When sample sizes are small, different studies could well generate very different false-positive rates if only because accuracy varies, both within and across examiners. Testing different samples of examiners at different times therefore will show different levels of performance. A common response to this sampling variability is a confidence interval (CI). A CI is intended to demarcate a range of possible values that might plausibly include the value that an ideal study of all examiners at all times would find.

The report advocates the use of an upper limit of a one-sided 95% CI for the false-positive rates instead of, or perhaps in addition to, the observed rates themselves. Some of the report’s statements about CIs and what to report are collected in an appendix to this posting. They have led to claims of a very large false-positive error rate for latent fingerprint identification. (See On a “Ridiculous” Estimate of an “Error Rate for Fingerprint Comparisons,” Dec. 10, 2016.)

A previous posting on "PCAST’s Sampling Errors" identified problems with the specifics of PCAST’s understanding of the meaning of a CI, with the technique it used to compute CIs for the performance studies it reviewed, and with the idea of substituting a worst-case scenario (the upper part of a CI) for the full range of the interval. Informing the factfinder of plausible variation both above and below the point estimate — is fairer to all concerned, and that interval should be computed with techniques that will not create distracting arguments about the statistical acumen of the expert witness.

This posting elaborates on these concerns. Forensic scientists and criminalists who are asked to testify to error probabilities (as they should) need to be aware of the nuances lest they be accused of omitting important information or using inferior statistical methods. I provide a few tables that display PCAST’s calculations of the upper limits of one-sided 95% CIs; two-sided CIs computed with the same method for ascertaining the width of the intervals; and CIs with methods that PCAST listed but did not use.

The discussion explains how to use the statistical tool that PCAST recommended. It also shows that there is potential for confusion and manipulation in the reporting of confidence intervals. This does not mean that such intervals should not be used — quite the contrary, they can give a sense of the fuzziness that sampling error creates for point estimates. Contrary to the recommendation of the PCAST report, however, they should not be presented as if they give the probability that an error probability is as high as a particular value.

At best, being faithful to the logic behind confidence intervals, one can report that if the error probability were that large, then the probability of the observed error rate or a smaller one would have some designated value. To present the upper limit of a 95% CI as if it states that the probability is “at least 5%” that the false-positive error probability could be “as high as” the upper end of that CI — the phrasing used in the report (p. 153) — would be to succumb to the dreaded “transposition fallacy” that textbooks on statistics abjure. (See also David H. Kaye, The Interpretation of DNA Evidence: A Case Study in Probabilities, National Academies of Science, Engineering and Medicine, Science Policy Decision-making Educational Modules, June 16, 2016.)

I. PCAST’s Hypothetical Cases

The PCAST Report gives examples of CIs for two hypothetical validation studies. In one, there are 25 tests of examiner’s ability to use features to classify pairs according to their source.  This hypothetical experiment establishes that the examiners made x = 0 false positive classifications in n = 25 trials. The report states that “if an empirical study found no false positives in 25 individual tests, there is still a reasonable chance (at least 5 percent) that the true error rate might be as high as roughly 1 in 9.” (P. 153.)

I think I know what PCAST is trying to say, but this manner of expressing it is puzzling. Let the true error rate be some unknown, fixed value θ. The sentence in the report might amount to an assertion that the probability that θ is roughly 1 in 9 is at least 5%. In symbols,
Pr(θ ≈ 1/9 | x = 0, n = 25) ≥ 0.05. 
Or does it mean that the probability that θ is roughly 1/9 or less is 5% or more, that is,
Pr(θ ≤ 1/9 | x = 0, n = 25) ≥ 0.05? 
Or does it state that the probability that θ is roughly 1/9 or more is 5% or more, that is,
Pr(θ ≥ 1/9 | x = 0, n = 25) ≥ 0.05?

None of these interpretations can be correct. Theta is a parameter rather than a random variable. From the frequentist perspective of CIs, it does not have probabilities attached to it. What one can say is that, if an enormous number of identical experiments were conducted, each would generate some point estimate for the false positive probability θ in the population. Some of these estimates x/n would be a little higher than θ; some would be a little lower (if θ > 0); some would a lot higher; some a lot lower (if θ ≫ 0); some would be spot on. If we constructed a 95% CI around each estimate, about 95% of them would cover the unknown θ, and about 5% would miss it. (I am not sure where the "at least 5%" in the PCAST report comes from.) Likewise, if we constructed a 90% CI for each experiment, about 90% would cover the unknown θ, and about 10% would miss it.

In assessing a point estimate, the width of the interval is what matters. At a given confidence level, wider intervals signal less precision in the estimate. The 90% CI would be narrower than the 95% one — it would have the appearance of greater precision, but that greater precision is illusory.  It just means that we can narrow the interval by being less “confident” about the claim that it captures the true value θ. PCAST uses 95% confidence because 95% is a conventional number in many (but not all) fields of scientific inquiry -- a fact that greatly impressed Justice Breyer in oral argument in Hall v. Florida.

In sum, 95% two-sided CIs are useful for manifesting the fuzziness that surrounds any point estimate because of sampling error. But they do not answer the question of what probability we should attach to the claim that “the true error rate might be as high as roughly 1 in 9.” Even with a properly computed CI that goes from 0 to 1/9 (which we can write as [0, 1/9]), the most we can say is that the process used to generate such CIs will err about 5% of the time. (It is misleading to claim that it will err “at least 5%” of the time.) We have a single CI, and we can plausibly propose that it is one of those that does not err. But we cannot say that 95% or fewer of the intervals [0, 1/9] will capture θ. Hence, we cannot say that “there is ... at least [a] 5 percent [chance] that the true error rate [θ] might be as high as roughly 1 in 9.”

To reconstruct how PCAST computed “roughly 1 in 9,” we can use EpiTools, the web-based calculator that the report recommended. This tool does not have an explicit option for one-sided intervals, but a 95% one-sided CI leaves 5% of the probability mass in a single tail. Hence, the upper limit is equal to that for a two-sided 90% CI. This is so because a 90% CI places one-half of the 10% of the mass that it does not cover in each tail. Figure 1 shows the logic.

Figure 1. Graphical Representation of PCAST's
Upper Limit of a One-sided 95% CI (not drawn to scale)
 95% CI (two-sided)
       **
      *****
     ********
    ************
   ****************
*************************
--[--------------------]------------> x/n
Lower 2.5% region       Upper 2.5% region

 90% CI (two-sided)
       **
      *****
     ********
    ************
  *****************
*************************
---[---------------]--------------> x/n
Lower 5% region     Upper 5% region

PCAST: Report the interval from
the observed x/n to the start of the upper 5% region? 
Or just report where the upper 5% region starts?

---[---------------]--------------> x/n
Lower 5% region     Upper 5% region

Inputting n = 25, x = 0, and confidence = 90% yields the results in Table 1.

Table 1. Checking and Supplementing PCAST’s CIs
in Its First Hypothetical Case (x/n = 0/25)

Upper One-sided 95% CI Limit Upper Two-sided 95% CI Limit
Clopper-Pearson 0.1129 = 1/9 0.1372 = 1/7
Wilson 0.0977 = 1/10 0.1332 = 1/8
Jeffreys 0.0732 = 1/14 0.0947 = 1/11
Agresti-Coull 0.1162 = 1/9 0.1576 = 1/6

The Wilson and Jeffreys methods, which are recommended in the statistics literature cited by PCAST, give smaller upper bounds on the false-positive error rate than the Clopper-Pearson method that PCAST uses. The recommended numbers are 1 in 10 and 1 in 14 compared to PCAST’s 1 in 9.

On the other hand, the upper limit for a two-sided 95% CI for the Wilson and Jeffreys tests are 1 in 8 and 1 in 11. In this example (and in general) using the one-sided interval has the opposite effect from what PCAST may have intended. PCAST wants to keep juries from hearing many false-positive-error probabilities that are below θ at the cost of giving them estimates that are above θ. But as Figure 1 illustrates, using the upper limit of a 90% two-sided interval to arrive at a one-sided 95% CI lowers the upper limit compared to the two-sided 95% CI. PCAST’s one-sided intervals do less, not more, to protect defendants from estimates of error false-positive error probabilities that are too low.

Of course, I am being picky. What is the difference if the expert reports that the false-positive probability could be 1 in 14 instead of PCAST’s upper limit of 1 in 9? The jury will receive a similar message — with perfect scores on only 25 relevant tests of examiners, one cannot plausibly claim that examiners rarely err. Another way to make this point is to compute the probability of the study’s finding so few false positives (x/n = 0/25) when the probability of an error on each independent test is 1 in 9 (or any other number that one likes). If 1/9 is the binomial probability of a false-positive error, then the chance of x = 0 errors in 25 tests of (unbeknownst to the examiners) same-source specimens is (1 – 1/9)25 = 0.053.

At this point, you may say, wait a minute, this is essentially the 5% figure given by PCAST. Indeed, it is, but it has a very different meaning. It indicates how often one would see studies with a zero false-positive error rate when the unknown, true rate is actually 1/9. In other words, it is the p-value for the data from the experiment when the hypothesis θ = 1/9 is true. (This is a one-tailed p-value. The expected number of false positives is 25(1/9) = 2.7. The probability of more than 6 or more false positives is 5.3%. So the two-tailed p-value is 10.5%. Only about 1 time in ten would studies with 25 trials produce outcomes that diverged at least much as this one did from what is statistically expected if the probability of error in each trial with different-source specimens really is 1/9.) Thus, the suggestion that the true probability is 1/9 is not grossly inconsistent with the data. But the data are not highly probable under the hypothesis that the false-positive error probability is 1/9 (or any larger number).

PCAST also gives some numbers for another hypothetical case. The report states that
[I]f a study finds zero false positives in 100 tries, the four methods mentioned give, respectively, the values 0.030, 0.026, 0.032, and 0.019 for the upper 95 percent confidence bound. From a scientific standpoint, any of these might appropriately be reported to a jury in the context "the false positive rate might be as high as."
The output of EpiTools is included in Table 2.

Table 2. Supplementing PCAST’s CIs
in Its Second Hypothetical Case (x/n = 0/100)

Upper One-sided 95% CI Limit Upper Two-sided 95% CI Limit
Clopper-Pearson 0.0295 = 1/34 0.0362 = 1/28
Wilson 0.0263 = 1/38 0.0370 = 1/27
Jeffreys 0.0190 = 1/53 0.0247 = 1/40
Agresti-Coull 0.0317 = 1/32 0.0444 = 1/23

Again, to the detriment of defendants, the recommended methods give smaller upper bounds than a more appropriate two-sided interval. For example, PCAST’s 90% Clopper-Pearson interval is [0, 3%], while the 95% interval is [0, 4%]. A devotee of the Jeffreys method (or a less scrupulous expert witness seeking to minimize the false positive-error risk) could report the smallest interval of [0, 2%].

II. Two Real Studies with Larger Sample Sizes

The two hypotheticals are extreme cases. Sample sizes are small, and the outcomes are extreme — no false-positive errors at all. Let’s look at examples from the report that involve larger samples and higher observed error rates.

The report notes that in Langenburg, Champod, and Genessay (2012),
For the non-mated pairs, there were 17 false positive matches among 711 conclusive examinations by the experts. The false positive rate was 2.4 percent (upper 95 percent confidence bound of 3.5 percent). The estimated error rate corresponds to 1 error in 42 cases, with an upper bound corresponding to 1 error in 28 cases.
P. 93 (notes omitted). Invoking EpiTools, one finds that

Table 3. Supplementing PCAST’s CIs
for Langenburg et al. (2012) (x/n = 17/711)

Upper One-sided 95% CI Limit Lower Two-sided 95% CI Limit Upper Two-sided 95% CI Limit
Clopper-Pearson 0.0356 = 1/28 0.0140 = 1/71 0.0380 = 1/26
Wilson 0.0353 = 1/28 0.0150 = 1/67 0.0380 = 1/26
Jeffreys 0.0348 = 1/29 0.0145 = 1/69 0.0371 = 1/27
Agresti-Coull 0.0355 = 1/28 0.0147 = 1/68 0.0382 = 1/26

As one would expect for a larger sample, all the usual methods for producing a binomial CI generate similar results. The PCAST one-sided interval is [2.4%, 3.6%] compared to a two-sided interval of [1.4%, 3.8%].

For a final example, we can consider PCAST's approach to sampling error for the FBI-Noblis study of latent fingerprint identification. The report describes two related studies of latent fingerprints, both with large sample sizes and small error rates, but I will only provide additional calculations for the 2011 one. The report describes it as follows:
The authors assembled a collection of 744 latent-known pairs, consisting of 520 mated pairs and 224 non-mated pairs. To attempt to ensure that the non-mated pairs were representative of the type of matches that might arise when police identify a suspect by searching fingerprint databases, the known prints were selected by searching the latent prints against the 58 million fingerprints in the AFIS database and selecting one of the closest matching hits. Each of 169 fingerprint examiners was shown 100 pairs and asked to classify them as an identification, an exclusion, or inconclusive. The study reported 6 false positive identifications among 3628 nonmated pairs that examiners judged to have “value for identification.” The false positive rate was thus 0.17 percent (upper 95 percent confidence bound of 0.33 percent). The estimated rate corresponds to 1 error in 604 cases, with the upper bound indicating that the rate could be as high as 1 error in 306 cases.
The experiment is described more fully in Fingerprinting Under the Microscope: A Controlled Experiment on the Accuracy and Reliability of Latent Print Examinations (Part I), Apr. 26, 2011, et seq. More detail on the one statistic selected for discussion in the PCAST report is in Table 4.

Table 4. Supplementing PCAST’s CIs
for Ulery et al. (2011) (x/n = 6/3628)

Upper One-sided 95% CI Limit Lower Two-sided 95% CI Limit Upper Two-sided 95% CI Limit
Clopper-Pearson 0.0033 = 1/303 0.0006 = 1/1667 0.0036 = 1/278
Wilson 0.0032 = 1/313 0.0008 = 1/1250 0.0036 = 1/278
Jeffreys 0.0031 = 1/323 0.0007 = 1/1423 0.0034 = 1/294
Agresti-Coull 0.0033 = 1/303 0.0007 = 1/1423 0.0037 = 1/270

The interval that PCAST seems to recommend is [0.17%, 0.33%]. The two-sided interval is [0.06%, 0.36%]. Whereas PCAST would have the expert testify that the error rate is "as high as 1 error in 306 cases," or perhaps between "1 error in 604 cases [and] 1 error in 306 cases," the two-sided 95% CI extends from 1 in 1667 on up to 1 in 278.

Although PCAST's focus on the high end of estimated error rates strikes me as tendentious, a possible argument for it is psychologically and legally oriented. If jurors would anchor on the first number they hear, such as 1/1667, they would underestimate the false-positive error probability. By excluding lower limits from the presentation, we avoid that possibility. Of course, we also increase the risk that jurors will overestimate the effect of sampling error. A better solution to this perceived problem might be to present the interval from highest to lowest rather than ignoring the low end entirely.

APPENDIX

PCAST is less than pellucid on whether a judge or jury should learn of (1) the point estimate together with an upper limit or (2) only the upper limit. The Council seems to have rejected the more conventional approach of giving both end points of a two-sided CI. The following assertions suggest that the Council favored the second, and most extreme approach:
  • [T]o inform jurors that [the] only two properly designed studies of the accuracy of latent fingerprint analysis ... found false positive rates that could be as high as 1 in 306 in one study and 1 in 18 in the other study ... would appropriately inform jurors that errors occur at detectable frequencies, allowing them to weigh the probative value of the evidence.” (P. 96.)
  • The report states that "the other (Miami-Dade 2014 study) yielded a considerably higher false positive rate of 1 in 18." (P. 96.) Yet, 1 in 18 was not the false-positive rate observed in the study, but, at best, the upper end of a one-sided 95% CI above this rate.
Other parts of the report point in the other direction or are simply ambiguous. Examples follow:
  • If firearms analysis is allowed in court, the scientific criteria for validity as applied should be understood to require clearly reporting the error rates seen in appropriately designed black-box studies (estimated at 1 in 66, with a 95 percent confidence limit of 1 in 46, in the one such study to date). (P. 112)
  • Studies designed to estimate a method’s false positive rate and sensitivity are necessarily conducted using only a finite number of samples. As a consequence, they cannot provide “exact” values for these quantities (and should not claim to do so), but only “confidence intervals,” whose bounds reflect, respectively, the range of values that are reasonably compatible with the results. When reporting a false positive rate to a jury, it is scientifically important to state the “upper 95 percent one-sided confidence bound” to reflect the fact that the actual false positive rate could reasonably be as high as this value. 116/ (P. 53)
  • The upper confidence bound properly incorporates the precision of the estimate based on the sample size. For example, if a study found no errors in 100 tests, it would be misleading to tell a jury that the error rate was 0 percent. In fact, if the tests are independent, the upper 95 percent confidence bound for the true error rate is 3.0 percent. Accordingly a jury should be told that the error rate could be as high as 3.0 percent (that is, 1 in 33). The true error rate could be higher, but with rather small probability (less than 5 percent). If the study were much smaller, the upper 95 percent confidence limit would be higher. For a study that found no errors in 10 tests, the upper 95 percent confidence bound is 26 percent—that is, the actual false positive rate could be roughly 1 in 4 (see Appendix A). (P. 53 n. 116.)
  • In summarizing these studies, we apply the guidelines described earlier in this report (see Chapter 4 and Appendix A). First, while we note (1) both the estimated false positive rates and (2) the upper 95 percent confidence bound on the false positive rate, we focus on the latter as, from a scientific perspective, the appropriate rate to report to a jury—because the primary concern should be about underestimating the false positive rate and the true rate could reasonably be as high as this value. 262/ (P. 92.)
  • Since empirical measurements are based on a limited number of samples, SEN and FPR cannot be measured exactly, but only estimated. Because of the finite sample sizes, the maximum likelihood estimates thus do not tell the whole story. Rather, it is necessary and appropriate to quote confidence bounds within which SEN, and FPR, are highly likely to lie. (P. 152.)
  • For example, if a study finds zero false positives in 100 tries, the [Clopper-Pearson/Exact Binomial method, the Wilson Score interval, the Agresti-Coull (adjusted Wald) interval, and the Jeffreys interval] give, respectively, the values 0.030, 0.026, 0.032, and 0.019 for the upper 95 percent confidence bound. From a scientific standpoint, any of these might appropriately be reported to a jury in the context “the false positive rate might be as high as.” (In this report, we used the Clopper-Pearson/Exact Binomial method.) (P. 153.)